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European Heart Journal 1980 1(1):73-79;
Copyright © 1980 by the European Society of Cardiology.
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© 1980 The European Society of Cardiology

Multifactorial trial in the prevention of coronary heart disease: 1. Recruitment and initial findings

WORLD HEALTH ORGANIZATION EUROPEAN COLLABORATIVE GROUP*,{dagger}

World Health Organization Copenhagen, Denmark

Received 21 August 1979; .

{dagger}Requests for reprints to: Professor G. Rose, London School of Hygiene and Tropical Medicine, Keppel St., London WC1, England.

Centres in five countries (Belgium, Italy, Poland, Spain, U.K.) have collaborated in a trial of multifactorial prevention of coronary heart disease in industrial populations (63 732 men aged 40–59 years, employed in 88 factories). Factories rather than individuals were randomized, in order that health education could be given to the whole of each intervention unit; this method, not previously used in a preventive trial, produced well balanced intervention and control groups. Comparability of screening results was achieved by use of standardized examination techniques, with internal and external quality control of clinical as well as laboratory methods. Prevalence estimates are given for each participating country, both for risk factors and for measures of myocardial ischaemia and intermittent claudication. An overall estimate ofCHD risk (multiple logistic function) was highest in Belgium, 44% above that for Poland (the lowest). Poland nevertheless had the highest rates for history of possible myocardial infarction and for major Q/QS findings. Centres varied widely in the contribution of each factor to total risk, as well as showing wide variation in risk between factories within each country.

Key Words: Coronary heart disease • prevention • risk factor • prevanlence • trial design • intermittent claudication


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