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European Heart Journal 1980 1(4):263-268;
Copyright © 1980 by the European Society of Cardiology.
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© 1980 The European Society of Cardiology

Depressive cardiac reflex elicited by angiographic contrast medium and its inhibition by lidocaine

A. VOGT, H. DAL RI, G. SCHMIDT and H. KREUZER

Medizinische Universitätsklinik Abteilung Kardiologie und Pharmakologisches Institut der Universität, D-3400 Göttingen, West Germany

Received 2 April 1980; .

Requests for reprints to: Dr. med. Albrecht Vogt, Medizinische Universitätsklinik, Robert-Koch-Strasse 40, D-3400 Gottingen, West Germany.

A depressive cardiac reflex elicited by angiographic contrast medium was investigated in anesthetized cats. Injection of 1–2 ml amidotrizoate (Urografin 76R) into the aortic root evoked total inhibition of cardiac sympathetic nerve activity, bradycardia and decrease of blood pressure. This proved to be a reflex reaction, since it was absent after vagotomy. The same reflex was elicited by intrapericardial injection of the contrast, indicating its cardiac origin. Hyperosmolic solution of urea was also able to cause this depressive reaction, whereas injection of the non-ionic contrast medium metrizamide (AmipaqueR) resulted in significantly less cardiovascular depression. This indicates that the high osmolarity of the dye is the exciting factor for the reflex. The reflex was dose-dependently and reversibly inhibited by i.v.-infusion of lidocaine.

Key Words: Cardiac reflexes • sympathetic activity • coronary angiography • radioopaque contrast


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