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European Heart Journal 1980 1(4):269-274;
Copyright © 1980 by the European Society of Cardiology.
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© 1980 The European Society of Cardiology

Treatment of stable angina pectoris with verapamil hydrochloride: a double blind cross-over study

M. L. SIMOONS, M. TAAMS, J. LUBSEN and P. G. HUGENHOLTZ

Thoraxcenter, Erasmus University Rotterdam, The Netherlands

Received 20 March 1980; revised 19 May 1980; .

Requests for reprints to: Maarten L. Simoons, M.D., Thoraxcenter. Erasmus University, P.O. Box 1738, Rotterdam, The Netherlands.

Verapamil hydrochloride, a calcium antagonist, has been recommended for the treatment of angina pectoris. The effectiveness of 3 x 120 mg verapamil was tested in 33 male patients with stable angina pectoris. The drug reduced the incidence of anginal episodes from 15 (1–98) to two (0–85) in four weeks (median, range); P < 0.01. The nitroglycerin consumption was similarly reduced. Exercise tolerance on a bicycle ergometer improved on the average by 10 W(P < 0.05). No side effects were observed.

It is concluded that verapamil is an effective drug in the treatment of stable angina pectoris.

Key Words: Stable angina • exercise testing


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