Skip Navigation

European Heart Journal 1980 1(5):319-326;
Copyright © 1980 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by MARCHIONNI, N.
Right arrow Articles by BERTINI, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MARCHIONNI, N.
Right arrow Articles by BERTINI, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1980 The European Society of Cardiology

Hemodynamic effects Of Dixogin in acute myocardial infarction

N. MARCHIONNI, A. VANNUCCI, R. PINI, B. GREPPI, A. CONTI, M. DI BARI and G. BERTINI

Coronary Care Unit, ‘Carlo Fumagalli’ Institute of Gerontology, University of Florence Florence, Italy

Received 27 February 1980; revised 10 May 1980; .

Requests for reprints to: Dr. N. Marchionni, Coronary Care Unite, ‘Carlo Fumagalli’, Institute of Gerontology, University of Florence, Florence 501 39, Italy.

Hemodynamic effects of 0.50 mg of i.v. Digoxin were studied in 25 patients (18 males and seven females, with a mean age of 66.0 ± 8.7 years) with an acute myocardial infarction (AMI) who underwent a right heart catheterization and hemodynamic monitoring in the CCU.

Heart rate (HR) was reduced from 97.16 ± 16.41 to 91.00 ± 16.85 beals/min (P < 0.01); cardiac index (CI) increased from a mean value of 2.16 ± 0.49 to 2.55 ± 0.70 l/min/m2 (P < 0.001); stroke index (SI) and left ventricular stroke work index (SWI) also improved from 22.46 ± 4.11 to 28.44 ± 7.61 ml/m2 and from 27.52 ± 5.71 to 36.04 ± 9.65 gm-m/m2 (P < 0001).

Systolic (SAP) and diastolic (DAP) arterial pressure slightly but significantly increased (P < 0.01) from 121.56 ±16.61 and 75.08 ± 9.03 mm Hg respectively, to 126.80 ± 16.28 and 77.72 ± 9.25 mm Hg; pulmonary artery mean pressure (PMP) decreased from 22.30 ± 8.22 to 20.48 ± 5.47 mm Hg (P < 0.05).

The patients were subdivided into two hemodynamic classes, according to the values of the PMP measured in basal conditions: group 1 (PMP ≤ 19 mm Hg): 11 patients (44.0%); group 2 (PMP > 19 mm Hg): 14 patients (56.0%).

Hemodynamic effects of i.v. Digoxin were analysed separately in each class, and the results were compared.

No difference was observed between the data from the two groups, except for PMP. This parameter was unchanged after Digoxin in group 1, while in group 2 it was reduced from 26.39 ± 5.29 to 23.18 ± 5.76 mm Hg. Furthermore, HR did not vary and DAP significantly increased only in group 1 (hypovolemic patients) while HR significantly decreased and DAP remained unchanged in the group of patients with a PMP > 19 mm Hg.

We concluded that Digoxin treatment during AMI can favourably affect the circulatory conditions primarily in cases with a moderate left ventricular failure. The beneficial effects of the drug seemed to be less evident when administered to patients with almost normal pump function or with extreme degrees of left ventricular failure.

Key Words: Acute myocardial infarction • cardiac glycocides • hemodynamic monitoring


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.