Skip Navigation

European Heart Journal 1980 1(5):335-343;
Copyright © 1980 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by EDVARDSSON, N.
Right arrow Articles by OLSSON, S.B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by EDVARDSSON, N.
Right arrow Articles by OLSSON, S.B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1980 The European Society of Cardiology

Sotalol-induced delayed ventricular repolarization in man*

N. EDVARDSSON, I. HIRSCH, H. EMANUELSSON, J. PONTÉN and S.B. OLSSON

Department of Cardiology, Med. Clin. I, Sahlgrenska Hospital S-413 45 Göteborg, Sweden

Received 31 July 1980; .

Requests for reprints to: Dr Edvardsson, Department of Cardiology, Med. Clin. I. Sahlgrenska Hospital, S-413 45 Göteberg, Sweden

Sotalol is the only beta-adrenergic blocking agent, that has been shown to produce delayed repolarization following acute administration. In this study an intravenous injection of 40–100 mg sotalol was given to eight patients with chronic atrial fibrillation. One patient was reverted to sinus rhythm, while the other patients were electro-converted 2 h after the injection. Three patients still in sinus rhythm 24 h later received chronic treatment for at least 12 weeks. They maintained sinus rhythm throughout the study.

Identical electrophysiological investigations were performed after the acute injection and after chronic treatment. Following acute administration, sotalol produced a consistent increase in the ventricular repolarization time as measured from refractory periods and monophasic action potential duration, the change being of the magnitude of 13 to 17%. After chronic treatment the three remaining patients still showed an increase in the ventricular repolarization time, but no conclusions can be made from these few observations. However, the study confirms the existence of a class III mode of action at the cellular level following intravenous sotalol injections of40–100 mg in man.

Key Words: Sotalol • electrophysiology • repolarization • monophasic action potential


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.