Skip Navigation

European Heart Journal 1989 10(1):40-47;
Copyright © 1989 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by KIRCH, W.
Right arrow Articles by STORSTEIN, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KIRCH, W.
Right arrow Articles by STORSTEIN, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 The European Society of Cardiology

Digitoxin in patients with hepatorenal insufficiency after repeated oral administration

W. KIRCH*,, E. E. OHNAHUS*, J. PABST* and L. STORSTEIN{dagger}

*Medical Hospital, Christian-Albrechts-University Kiel West Germany
{dagger}Division of Clinical Pharmacology and Toxicology Ulleval Hospital Oslo Norway

Received 12 May 1988; revised 2 September 1988; .

Address for correspondence Professor Dr W. Kirch, I Medizinische Klinik, Christian-Albrechts-Universitat, Schittenhelmstrasse 12, D-2300 Kiel, 1, FRG.

Abstract

Following chronic oral administration of digitoxin 01 mg day-1 the pharmacokinetics ofthis glycoside were studied in seven patients with hepatorenal insufficiency and were compared with those of seven healthy volunteers. Liver cirrhosis of the patients was confirmed by liver biopsy. Mean creatinine clearance of the healthy subjects was 129.7 ± 3.3 ml min-1 (X ± SEM), that of the patients was 25.6 ± 20.4 ml min-1. Mean antipyrine clearance (parameter of oxidative liver function) was 49.7 ± 6.0 ml min-1 in the volunteers and 22.0 ± 2.9 ml min-1 in the patients. Plasma protein binding of digitoxin (PPB) was95.0 ± 1.1% in the patients and 96.7 ± 0.6% in the healthy subjects (n.s.). Total body clearance of digitoxin (Cltos) was 00728 ± 00120 ml min-1 kg-1 in the patients and 0.0615 ± 0.0027 ml min-1 kg-1 in normals (n.s.)). Mean steady state plasma levels (Css) of the patients were 18.3 ± 4.7 ng ml-1and 15.8 ± l.3 ng ml-1 in the normals (n.s.). Our data obtained from chronic oral administration do not indicate a reduced total body clearance of digitoxin in patients with hepatorenal insufficiency

Key Words: Digitoxin • chronic oral administration • hepatorenal insufficiency


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.