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European Heart Journal 1989 10(10):950-954;
Copyright © 1989 by the European Society of Cardiology.
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© 1889 The European Society of Cardiology

Generalized seizures as the presentation of flecainide toxicity

A. KENNERDY, P. THOMAS and D. J. SHERIDAN

Department of Cardiology, St. Mary's Hospital Medical School London, U.K.

Received 20 January 1989; revised 10 March 1989; .

Requests for reprints to: Prof D. J. Sheridan, Department of Cardiology, St Mary's Hospital Medical School, Praed Steet, London W2 1 NY, U.K.

Abstract

A 12-year-old girl developed generalized tonic-clonic seizures following ingestion of flecainide 1500 mg (15 tablets). At presentation, the electrocardiogram showed marked prolongation of the JT interval and marked increase in QRS duration. The initial plasma flecainide level was >4µg ml–1. Supportive therapy was instituted and complete recovery occurred within 48 h. The electrocardiogram returned to normal. The management of class 1 antiarrhythmic agent toxicity is briefly outlined and the association of antiarrhythmic drug toxicity with seizures is reviewed.

Key Words: Antiarrhythmic agent • flecainide • toxicity • tonic-clonic seizures


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