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European Heart Journal 1989 10(11):1041-1044;
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Penicillamine-induced polymyositis with complete heart block

P. D. CHRISTENSEN and K. E. SØRENSEN

University Department of Cardiology, Skejby Hospital Aarhus, Denmark

Received 18 May 1988; revised 25 January 1989; .

Address for correspondence: K. E. Sørensen. University Department of Cardiology, Skejby Hospital, DK-8200 Aarhus N, Denmark

Abstract

Complete heart block with severe Adams-Stokes attacks and polymyositis was observed in a 69-year-old man following 6 weeks penicillamine treatment for suspected rheumatoid arthritis. After drug withdrawal the muscle enzymes and the cardiac rhythm gradually normalized, only leaving a right bundle branch block.

Although this is the first report to show that severe cardiac damage associated with penicillamine-induced polymyositis is a potentially reversible condition, the severity of the three cases reported so far warrants close observation for cardiac involvement in patients with penicillamine-induced polymyositis.

Key Words: Complete heart block • polymyositis • penicillamine


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