Copyright © 1989 by the European Society of Cardiology.
© 1989 The European Society of Cardiology
Effects of metoprolol on mortality and late infarction in diabetics with suspected acute myocardial infarction. Retrospective data from two large studies
Department of Medicine I, Sahlgrens Hospital, University of Goteborg and Department of Cardiology Skövde Hospital Sweden
Received 15 January 1988; revised 3 October 1988; .
Address for reprints: Dr Klas Malmberg, Department of Cardiology, Kämsjukhuset, S-541 85 Skövde, Sweden.
Abstract
From two large scale studies in patients with suspected acute myocardial infarction we report the outcome in diabetics after treatment with either metoprolol or placebo. In the Goteborg Metoprolol Trial mortality at 3 months was reduced by metoprolol from 17.9% to 7.5% and late infarction was reduced from 16.4% to 3.8%. In the MIAMI Trial, mortality was decreased by metoprolol from 11.3% to 5.7% and the occcurence of late infarction was decreased from 4.5% to 31% during 15-day follow-up. Compared with the overall results, the effect of metoprolol on mortality appears particularly impressive in diabetics.
Key Words: Diabetics • metoprolol • myocardial infarction
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