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European Heart Journal 1989 10(5):445-450;
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Treatment of heart failure with diuretics: body compartments, renal function and plasma hormones

I.S. ANANAD*, N. VEALL{dagger}, G.S. KALRA*, R. FERRARI{ddagger}, G. SUTTON, D. LIPKIN§, P. HARRIS§ and P.A. POOLE-WILSON§,

*Postgraduate Institute of Medical Education and Research Chandigarh India
{dagger}MRC Clinical Research Centre Harrow U.K.
{ddagger}Department of Cardiology, University of Brescia Italy
Hillington Hospital Middlesex U.K.
§National Heart and Lung Institute and National Heart Hospital London U.K.

Received 1 July 1988; revised 15 November 1988; .

Correspondence to: Professor P. A. Poole-Wilson, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, U.K.

Abstract

Body fluid compartments, renal function and plasma hormones were measured in 13 patients with severe chronic heart failure, when the referring physician considered the patient to be appropriately treated. Although renal function was substantially impaired and plasma nor adrenaline, aldosterone and renin activity were elevated, fluid compartments were within the normal range. These results show that careful clinical assessment of patients by an experienced physician is a reliable method of assessing restoration of 'normal' body fluid volumes with diuretics.

Key Words: Heart failure • diuretics • hormones • kidney • fluid compartments


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