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European Heart Journal 1989 10(9):863-864;
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Elevated atrial natriuretic peptide level in giant right atrium complicating Marfan's syndrome

C.-K. WONG, C.-P. LAU, C.-H. CHENG, W.-H. LEUNG, T. Y. K. CHAN and -K.-K. PUN

Department of Medicine, University of Hong Kong, Queen Mary Hospital Hong Kong

Received 24 October 1988; revised 17 January 1989; .

Correspondence to: Dr C. K. Wong, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong

Abstract

We report a rare case of giant right atrial dilatation in a patient with Marfan's syndrome complicated by severe tricuspid regurgitation. Interestingly, the right atrial pressure was normal, but the atrial natriuretic peptide level was markedly elevated. We suggest that the underlying connective tissue abnormality had allowed extensive atrial distension which by causing an increased intramural tension according to Laplace's law stimulated atrial natriuretic peptide secretion.

Key Words: Giant right atrium • atrial natriuretic peptide • Marfan's syndrome


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