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European Heart Journal 1989 10(Supplement E):31-40; doi:10.1093/eurheartj/10.suppl_E.31
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Classification and action of antiarrhythmic drugs

U. Borchard, F. Berger and D. Hafner

Institute of Pharmacology, University of Düsseldorf, Federal Republic of Germany

Address for correspondence: Institute of Pharmacology, University of Düsseldorf, Moorenstrasse 5, D-4000 Düsseldorf, F.R.G.

A great number of antiarrhythmic drugs is available for the treatment of tachyarrhythmias. The classiffication of these drugs according to their action on different ionic channels of cardiac cells is discussed and summarized. Furthermore, drugs are characterized with respect to their mechanism of action on membrane currents and their action in different cardiac tissues. From the results, strategies may be developed which represent the basis for clinical application of antiarrhythmic drugs.

Key Words: Antiarrhythmic drugs • Na-channel blockers • Ca-channel blockers • K-channel blockers


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