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European Heart Journal 1989 10(Supplement F):164-167; doi:10.1093/eurheartj/10.suppl_F.164
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Response to histamine of the intact coronary system in an isolated rabbit heart preparation

R. Rösen, M. Hegner-Mai and W. Klaus

Pharmakologisches Institut der Universität Köln F.R.G.

Address for correspondence: Priv. Doz. Dr Renate Rosen, Gleuelerstr. 24, D-5000 Koln 41, F.R.G.

In isolated Langendorff-perfused rabbit hearts concentration-response relations for histamine were analysed with and without H2-receptor blocker cimetidine (10–5 moll–1). The diameter of large epicardial coronary arteries was determined by video angiometry. Global coronary flow and left ventricular isovolumetric pressure were continuously registered. Histamine concentration (10–7–6x10–6 mol l–1) reduced the diameter of large coronary arteries up to –50%, however, this vasoconstriction was maximal after 1 min and was then attenuated within the following 20 min. Coronary flow and left ventricular pressure were not significantly altered. In the presence of cimetidine the histamine-induced vasoconstriction was stabilized and not reversed with time. Moreover, the extent of vessel wall narrowing was intensified (up to –70%) when compared with histamine alone. Furthermore, severe functional myocardial failure was observed (flow reduction to 40% of control).

Key Words: Histamine • cimetidine • coronary arteries • vasoconstriction • H1- • H2-receptors • videoangiometry • Langendorff rabbit heart


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