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European Heart Journal 1989 10(Supplement F):2-5; doi:10.1093/eurheartj/10.suppl_F.2
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Coronary vasomotor tone: a heterogeneous entity

A. Maseri, C. Newman and G. Davies

Cardiovascular Research Unit, Royal Postgraduate Medical School, Hammersmith Hospital London, U.K.

Changes in coronary vasomotor tone are undoubtedly involved in the pathogenesis of many ischaemic coronary syndromes. The term coronary artery ‘spasm’ should be limited to the situations characterized by focal coronary constriction sufficient to cause transient total or sub-total coronary occlusion. Mild coronary artery constriction is also observed in many other situations, without even causing coronary artery occlusion. We present suggestive evidence that the mechanisms underlying coronary artery ‘spasm’ and ‘physiological’ coronary artery constriction are different.

Key Words: Ischaemic heart disease • coronary vasomotor tone • variant angina, spasm


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