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European Heart Journal 1989 10(Supplement F):22-27; doi:10.1093/eurheartj/10.suppl_F.22
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Flow-dependent regulation of coronary vasomotor tone

E. Bassenge

Institute of Applied Physiology, University of Freiburg F.R.G.

Address for correspondence: Professor Dr E. Bassenge, Institut f. Angewandte Physiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-7800 Freiburg i.Br., F.R.G.

Large coronary artery calibres are regulated by humoral factors (autacoids) released from the endothelial cell lining. Several hormones, transmitters and platelet-derived products like serotonin and ATP or acetylcholine, noradrenaline, and histamine, stimulate such an autacoid release and thus an endothelium-mediated dilation in addition to their direct constrictor effect on the vasculature. Another mechanical stimulus is the flow-induced shear stress acting as viscous drag upon the endothelial surface along with the pulsatile stretching of the endothelial lining, which causes, in a moment to moment fashion, a continuous adjustment of coronary calibres. With endothelial function impaired or absent as in atheromatosis or after balloon catheter denudation this adjustment is compromised. Thus unbalanced constrictor effects may become effective especially in the presence of a simultaneously reduced platelet antiaggregation.

Key Words: Endothelium mediated vasomotor control • stimulation of EDRF-release • pathophysiology of autacoid release


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