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European Heart Journal 1989 10(Supplement F):49-53; doi:10.1093/eurheartj/10.suppl_F.49
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Morphometric versus densitometric assessment of coronary vasomotor tone-an overview

P.-A. Doriot, N. Guggenheim, P.-A. Dorsaz and W. Rutishauser

Cardiology Center, University Hospital Geneva, Switzerland

Address for correspondence: P.-A. Doriot, Cardiology Center, University Hospital, CH-1211 Geneva 4, Switzerland

The main advantage of the morphometric approach is that the spatial orientation of the vessel with respect to the image intensifier is not very important. Its most severe limitations are that reasonable accuracy can only be obtained with circular lumina, and that accuracy decreases rapidly with the vessel diameter. The densitometric approach is much less dependent on the shape of the lumen and on the correct identification of the vessel wall in the image. A further essential advantage is that one measures directly the cross-sectional area of the vessel instead of a ‘diameter’ of low haemodynamic relevance. Severe requirements must however be met if the potential accuracy of densitometry is to be fully exploited. The morphometric approach seems thus preferable for absolute or relative diameter measurements on intact vessels, while densitometry is superior in case of irregular or small lumina. Morphometric calibration using the injection catheter can induce non-negligible errors in both approaches. Grid calibration is probably more accurate, but also more tedious. In the densitometric approach, ‘3D-calibration’ by help of a cube of known size allows also determination of the spatial orientation of the vessel in space. This solution requires however biplane imaging.

Key Words: Coronary vasomotor tone • coronary morphometry • coronary densitometry


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