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European Heart Journal 1989 10(Supplement F):60-65; doi:10.1093/eurheartj/10.suppl_F.60
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Influence of ionic and non-ionic radiographic contrast media on the vasomotor tone of epicardial coronary arteries

S. Jost, W. Rafflenbeul, U. Gerhardt, H. Hecker, U. Nellessen, G.-H. Reil and P. R. Lichtlen

Hannover Medical School Hannover, F.R.G.

Address for reprints: Dr Stefan Jost, Medizinische Hochschule Hannover, Abteilung Kardiologie, Postfach 61 01 80, D-3000 Hannover 61, F.R.G.

The effect of ionic and non-ionic contrast media on the vasomotility of epicardial coronary arteries was investigated in 21 patients during coronary angiography by use of either diatrizoate-76% (10 patients, group A) or iopromide-370 (11 patients, group B). Coronary angiograms were taken in RAO 30° projection before (=reference) and directly after (t0) diagnostic angiography of the left coronary artery (approx. 7 dye injections in approx. 7 min). Additional angiograms in the same projection followed after 1, 3, 6 and 10 min. Mean diameters of angiographically normal coronary segments were analysed with an automatic edge detection system (CAAS). With diatrizoate-76% coronary dilation at t0 averaged 18·9±6·7% (P<0·001); it correlated positively (P<0·001) with the number of diagnostic injections performed per min (mean 1·2±0·3 min–1), and negatively (P<0·5) with the time interval between the last diagnostic contrast injection and t0 (mean interval 73±35s). Coronary dilation was unchanged 1 min after t0 (18·3±5·4%, P<0·001) and was still present after 6 min (6·2±4·6%, P<0·01). With iopromide-370 coronary dilation at t0 was mild (5·4±4·3%; P<0·05); the subsequent injections led to minimal insignificant dilation.

It is concluded that in quantitative angiographic studies on changes in coronary vasomotor tone repeated coronary angiograms should be taken with non-ionic contrast media; furthermore adequate injection intervals of>3 min should be observed.

Key Words: Coronary vasomotor tone • contrast media • diatrizoate-76% • iopromide-370


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