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European Heart Journal 1990 11(1):90-91;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Calcific aortic stenosis in twins: A clue to its pathogenesis?

N. P. LEWIS and A. H. HENDERSON

Department of Cardiology. University OF Wales College of Medicine Cardiff, U.K.
*Department of Physiology, University Medical School

Received 14 April 1989; revised 27 February 1989; .

Correspondence: Professor A. H. Henderson, Department of Cardiology, University of Wala College of Medicine, Heath Park, Cardiff, CF4 4XN, U.K

Abstract

A pair of identical twins presented almost simultaneously at age 62 years with calcific aortic stenosis requiring surgery, one with bicuspid and one with tricuspid aortic valve. This suggests that bicuspid morphology may perhaps not be the cause, but may be a genetically linked marker of an inherited predisposition to calcific stenosis.

Key Words: Calcific aortic stenosis • bicuspid aortic valve • twins


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