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European Heart Journal 1990 11(10):916-924;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Influence of age and sex on left ventricular volumes and ejection fraction during upright exercise in normal subjects

L. T. YOUNIS, J. A. MELIN, A. R. ROBERT and J. M. R. DETRY

Division of Cardiology and the Center of Nuclear Medicine, University of Louvain Medical School Brussels, Belgium

Received 31 October 1989; revised 13 November 1989; .

Address for reprints. Jacques A. Melin, MD, University of Louvain Medical School, Box 5430, Avenue Hippocrate, 54, 1200 Brussels, Belgium.

Abstract

To determine the effects of age and sex on exercise left ventricular volume indexes and ejection fraction, a cross-sectional study was performed in 18 young volunteers (nine men and nine women) and in 17 older volunteers (nine men and eight women) without evidence of coronary artery disease by exercise electrocardio-graphic and thallium-201 criteria. All subjects performed a multistage maximal upright exercise with measurements of maximal oxygen consumption and heart rate; left ventricular ejection fraction and absolute volume indexes were measured at rest and during submaximal and maximal exercise using equilibrium radionuclide ventriculography. At rest, no effect of age or sex on any parameter was observed. At peak exercise, an age-related increase in mean blood pressure, end-diastolic and end-systolic volume indexes, and decrease in ejection fraction, cardiac index, heart rate and oxygen consumption were noticed. Sex had a significant effect on maximal workload, maximal oxygen consumption and ejection fraction.

Key Words: Exercise • aging • haemodynamics


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