Copyright © 1990 by the European Society of Cardiology.
© 1990 The European Society of Cardiology
Plasma renin activity and urine ß2-microglobulin during and after cardiopulmonary bypass: pulsatile vs non-pulsatile perfusion
*Department of Anaesthesiology and Surgical Intensive Care Belgium
Department of Cardiovascular and Thoracic Surgery, University of Liège Belgium
Received 6 February 1989; revised 30 October 1989; .
Correspondence address: J. L. Canivet, Department of Anaesthesi-ology, C.H.U. of Li
ge B35, 4000 Lige 1, Belgium
Abstract
Fourteen patients with normal preoperative renal function underwent aortocoronary bypass graft using cardiopulmonary bypass (CPB) with pulsatile (P; n = 7) or non pulsatile (NP; n = 7) perfusion. In the two groups prebypass values of plasma renin activity (PRA) and urine ß2-microglobulin (ß2-M) were within normal limits. PRA increased significantly during CPB and the first 6 h after CPB only in the non-pulsatile group. In both groups, the urine ß2-M level increased significantly during and after CPB; however, there was no significant difference in urine ß2-M levels between the two groups. Also, the amount of ß2-M excreted in urines per unit of time increased significantly in both groups during and after CPB; there was no significant difference between the two groups.
Key Words: Pulsatile perfusion • plasma renin activity • ß2-microglobulin
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