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European Heart Journal 1990 11(2):182-188;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Clinical outcome and left ventricular function 23 years after acute Coxsackie virus myopericarditis

J. REMES, M. HELIN, P. VAINO and P. RAUTIO

Departments of Medicine and Clinical Physiology, Kuopio University Central Hospital Kuopio, Finland

Received 30 May 1989; revised 17 July 1989; .

Address for correspondence Jouko Remes, MD, Kuopio University Central Hospital, Department of Medicine. SF-70210 Kuopio, Finland.

Abstract

The clinical outcome of 18 patients, who presented with a Coxsackie virus myopericarditis in 1965, was evaluated 23 years later. Five patients had died, two of them had had heart failure. Thirteen patients and 23 healthy control subjects underwent exercise testing with gas exchange analysis. Left ventricular (LV) peak filling rate (PFR) was estimated by digitized M-mode echocardiography. Left ventricular ejection fraction was measured at rest and during exercise by radionuclide angiography.All patients were free of cardiac symptoms. Their clinical examination and the chest X-ray were normal. Peak oxygen consumption was not decreased in the patient group compared with the control group. PFR was significantly lower in the patient group than in the control group, 10–2±0–4 vs 13–2±04 cms1, P<0001 (mean±SEM). LV ejection fraction was normal at rest in all patients (58±1percnt;). An abnormal LV ejection fraction response to exercise was observed in two patients. Our data indicate that long-term prognosis after acute Coxsackie virus myopericarditis is good in a majority of patients

Key Words: Myocarditis • myopericarditis • Coxsackie virus • left ventricular function • prognosis


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