Skip Navigation

European Heart Journal 1990 11(4):323-327;
Copyright © 1990 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by SCHWINGER, R. H. G.
Right arrow Articles by ERDMANN, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SCHWINGER, R. H. G.
Right arrow Articles by ERDMANN, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 The European Society of Cardiology

The effect of xamoterol in failing human myocardium

R. H. G. SCHWINGER, M. BÖHM and E. ERDMANN

Medizinische Klinik I der Universität München München, F.R.G.

Received 10 April 1989; revised 10 July 1989; .

correspondence to Prof: E. Erdmann, Universität München, Medizinische Klinik I, Marchiomnistrasse 15, D-8000 München 70, F.R.G.

Abstract

As the dual pharmacological action of partial ß1-adrenoceptor agonists should improve left ventricular function while also protecting the myocardium against excessive sympathetic stimulation they may be useful in the treatment of heart failure. Therefore, we studied the pharmacological effects of xamoterol (Corwin, ICl 118, 587), a compound with mixed agonist and antagonistic properties at cardiac ß-adrenoceptors in electrically driven human papillary muscle strips from failing human hearts. Specimens were obtained from patients with different grades of myocardialfailure who underwent mitral valve replacement (NYHA II-III) or heart transplantation (NYHA IV). Xamoterol (0.0001-10.0 µmol 1–1) produced only negative inotropic effects, as measured by changes in isometric force of contraction in diseased human papillary muscle strips. However, isoprenaline (0.0001-10 µmol l–1) and ouabain (0.01-0.3 µmol 1–1) enhanced force of contraction in the same hearts. Prestimulation with noradrenaline (3 µmol l–1) augmented the negative inotropic effect of xamoterol. It is concluded that xamoterol exerts primarily ß-adrenoceptor antagonistic activity in the failing human myocardium

Key Words: Xamoterol • positive inotropic agent • ß-adrenoceptor • heart failure • human myocardium


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
A. Bundkirchen, K. Brixius, B. Bolck, and R. H. G. Schwinger
Bucindolol Exerts Agonistic Activity on the Propranolol-Insensitive State of beta 1-Adrenoceptors in Human Myocardium
J. Pharmacol. Exp. Ther., March 1, 2002; 300(3): 794 - 801.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.