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European Heart Journal 1990 11(4):368-371;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Atrial natriuretic peptide release responds to atrial stretch and not to atrial pressure: observations during pericardiocentesis in a young woman

A. C. M. ONG*, C. E. HANDLER{dagger}, and J. D. H. SLATER*

*Cobbold Laboratories London
{dagger}Department of Cardiology, Middlesex Hospital London

Received 10 April 1989; revised 14 August 1989; .

Correspondence: Dr C. E. Handler. Dept of Cardiology, Middlesex Hospital, Mortimer Street, London, Wl N 8AA, U.K.

Abstract

The effect of pericardiocentesis on the plasma concentration of atrial natriuretic peptide was studied in a patient with cardiac tamponade. Plasma atrial natriuretic peptide concentrations rose sharply from 42 pmoll–11 to a maximum of l50 pmol l–11 with a corresponding fall in mean right atrial pressure from 20 mmHg to 6 mmHg. Our results suggest that atrial ‘stretch’ (or transmural pressure) rather than atrial pressure per se, is the primary stimulus for atrial natriuretic peptide release in man.

Key Words: Atrial natriuretic peptide • atrial stretch • atrial pressure • atrial distending pressure • artrial transmural pressure • pericardionentesis • cardiac temponade


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