Skip Navigation

European Heart Journal 1990 11(5):403-412;
Copyright © 1990 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by LEFKOWITZ, C. A.
Right arrow Articles by MCLAUGHLIN, P. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LEFKOWITZ, C. A.
Right arrow Articles by MCLAUGHLIN, P. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 The European Society of Cardiology

Validation of left ventricular function parameters acquired with the non-imaging nuclear probe: comparison with tantalum marker cine-fluoroscopy

C. A. LEFKOWITZ*,{ddagger},1, R. R. MILDENBERGER*,{ddagger}, P. LIU*,{ddagger}, B. P. KIMBALL*,{ddagger}, L. MICKLEBOROUGH, R. WEISEL, S. HOULE{dagger},¶ and P. R. MCLAUGHLIN*,{ddagger}

*Divisions of Cardiology Toronto General Hospital, University of Toronto
{dagger}Division of Nuclear Medicine Toronto General Hospital, University of Toronto
{ddagger}Department of Medicine Toronto General Hospital, University of Toronto
Department of Radiological Sciences Toronto General Hospital, University of Toronto

Received 6 August 1989; revised 1 August 1989; .

1Address for reprints Dr C A. Lefkowitaz, Division of Cardiology, Toronto General Hsopital, Eaton North 13-212, 200 Elizabeth St., Toronto, Ontario, Canada. MSG 1L7

Abstract

We evaluated the accuracy of the non-imaging nuclear probe for measuring various parameters of left ventricular function by comparing these with simultaneous measurements acquired via tantalum marker cine-fluoroscopy. Eight patients with surgically implanted mid-myocardial tantalum markers were studied during cardiac catheterization. High temporal resolution tantalum marker-derived volume/time curves were generated and calibrated to absolute endocardial volumes by comparison with contrast left ventricular angiography. Left ventricular function parameters were acquired at baseline and during atrial pacing, nitroprusside infusion and volume loading. Simultaneous measurements obtained with the nuclear probe and via tantalum marker cine-fluoroscopy were compared.

The following correlation coefficients were obtained: ejection fraction, r = 0.49, P<0.001; peak ejection rate, r = 0.41, P <001; mean ejection rate, r = 0.62, P < 0.001; time to peak ejection, r = 0.73, P < 0001; peak filling rate, r = 0.73, ? <0.001; time to peak filling, r = 0.58, P<0001. Relative changes in end-diastolic volume were accurately tracked by the nuclear probe in six of seven patients (r values 0.77–0.93).

These results suggest that measurements of certain left ventricular volume parameters with the nuclear probe may not accurately reflect true volume changes as measured by tantalum marker cine-fluoroscopy. Although, the probe may be useful in tracking relative changes in end-diastolic volume, we would advise caution in using this instrument for studies requiring accurate measurements of ejection and filling parameters

Key Words: Left ventricular function • nuclear probe • tantalum marker cine-fluoroscopy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.