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European Heart Journal 1990 11(5):447-453;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Transcutaneous nerve stimulation in patients with coronary arterial disease: Haemodynamic and biochemical effects

B. KAADA*,1, H. VIK-MO{dagger}, G. ROSLAND{dagger}, L. WOIE* and P. K. OPSTAD||

*Rogaland Central Hospital 4011 Stavanger, Norway
{dagger}Department of Clinical Physiology, University Hospital of Bergen Norway
||Norwegian Defence Research Establishment, Division of Toxicology 2007 Kjeller, Norway

Received 25 May 1989; revised 21 August 1989; .

1Correspondence Birger Kaada, MD, Rogaland Central Hospital, N-4011 Stavanger, Norway.

Abstract

Low-frequency transcutaneous nerve stimulation (TNS) is known to produce widespread and prolonged vasodilation in skin and muscles. In the present study the effects of low-frequency TNS on coronary and systemic haemodynamics, myocardial blood flow, myocardial oxygen consumption, myocardial free fatty acid andlactate uptake were measured at rest in 16 normotensive patients, with coronary heart disease, undergoing diagnostic cardiac catheterization. In addition, vasoactive intestinal polypeptides (VIP) and noradrenaline were measured in the coronary sinus and the aorta. The study was randomized and double-blind, with half of the patients serving as placebo controls. A stimulation period of 20 min caused a significant lowering of mean femoral arterial pressure and systemic vascular resistance measured at 15 and 30 min after the start of TNS (P<0–01). There was no significant change in the other parameters mentioned. The hypotonic effect is considered to be due to increased peripheral microcirculation resulting from sympatho-inhibition.

Key Words: Angina pectoris • blood pressure • coronary heart disease • myocardial blood flow • transcutaneous nerve stimulation • vasoactive intestinal polypeptides • noradrenaline


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