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European Heart Journal 1990 11(6):517-524;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Electrophysiology of heterotopic heart transplant: Experimental study in dogs

L. ALVAREZ*,, C. SCUDEROV*, J. ALZUETAI{dagger}, L. SILVA{dagger}, J. MARQUEZ-MONTES{dagger} and J. L. CASTILLO-OLIVARES*

*Service of Experimental Surgery, Hospital Puerto de Hierro, Universidad Autonoma Madrid Spain
{dagger}Arrhythmias Unit (Service of Cardiology), Hospital Puerto de Hierro, Universidad Autonoma Madrid Spain

Received 9 December 1988; revised 19 June 1989; .

Correspondence: L. Alvarez, San Gerardo 37, 28035 Madrid, Spain

Abstract

Electrophysiological properties were studied in a heterotopic heart transplant model developed in 44 dogs (Group I). Cycle length was 359.5 ± 55.2 ms in the recipient heart and 500.9 ± 77.9 ms in the donor heart (P<0.001). Sinoatrialconduction time was 38.6± 13.6 ms in the recipient heart and 38.6 ±10.4 ms in that of the donor (not –significant). The Wenckebach point was 175.4±31.1 ms in the recipient organ and 214.3 ± 42.6 ms in the donor heart (P < 0.001). The retrograde block point was 271.6 ± 48.0 ms in the recipient heart and 353.6±47.3 ms in that of the donor (P<0.01). The effective antegrade refractory period was 133.4 ±28.7 ms in the recipient heart and 167.3 ±46.3 ms in the donor organ (P< 0.001). An epicardial atrial cartography was performed at 44 preset points in both hearts, revealing a normal activation sequence and delays of 36.98 ms (mean 58 ms) in the recipient heart and from 39 to 59 ms (mean 50 ms) in the donor heart (not significant).

In another 11 dogs (Group II), the same electrophysiological study was carried out under basal conditions and after pharmacological blockade of the autonomic nervous system with atropine (004 mg (kg body weight)–1) andpropranolol (0.2 mg (kg body weight)–1). No significant differences were found in any of the parameters studied upon comparison of Group II animals in basal conditions with Group I recipients, and Group II dogs after blockade with Group I donors.

These results demonstrate that the differences in automatism, conduction and refractoriness between the donor and recipient hearts are not attributable to differences in the haemodynamic situation or in the anaesthetic technique, but to denervation.

Key Words: Electrophysiology • denervation • heterotopic heart transplantation


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