Skip Navigation

European Heart Journal 1990 11(6):552-559;
Copyright © 1990 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by VAN DER GlESSEN, W.J.
Right arrow Articles by VERDOUW, P.D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by VAN DER GlESSEN, W.J.
Right arrow Articles by VERDOUW, P.D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 The European Society of Cardiology

Nisoldipine improves blood flow to skeletal muscles in conscious pigs with chronic heart failure

W.J. VAN DER GlESSEN, L.J. VAN WOERKENS, P.R. SAXENA*, J.R.T.C. ROELANDT and P.D. VERDOUW

Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam Rotterdam, The Netherlands
*Department of Pharmacology, Erasmus University Rotterdam Rotterdam, The Netherlands

Received 13 June 1989; revised 6 October 1989; .

Correspondence: P.D. Verdouw, PhD, Laboratory for Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Betherlands.

Abstract

We studied the acute effects of the calcium antagonist nisoldipine in 10 conscious pigs with chronic heart failure. Left ventricular dysfunction was induced by permanent ligation of the left circumflex coronary artery. Two to three weeks after myocardial infarction the effects of four consecutive 10 min intravenous infusions of nisoldipine (0.05;0.1; 0.25 and 0.5 fig kg–1 min–1) or its solvent on systemic haemodynamics were evaluated. In addition, we used the radioactive microsphere technique to study the distribution of cardiac output after each dose of nisoldipine. Nisoldipine significantly (P<0.05) increased heart rate (from 144 ±9 to 161 ±8 beats min–1), cardiac output (from 21 ±0.1 to 2.9 ± 0.21 min–1), stroke volume (from 14 ±1 to 18 ±1 ml) and left ventricular dP/dtmax (from 2600 ± 100 to 3500 ± 250 mmHg s–1), but had no effect on arterial blood pressure. Left ventricular end-diastolic pressure (from 19±2 to 16±1 mmHg) and systemic vascular resistance (from 52 ±3 to 37 ±3 mmHg min l–1) decreased after nisoldipine. The nisoldipine-induced increase in cardiac output did not affect blood flow to the kidneys, brain, liver or skin, but perfusion of the stomach (84%), adrenals (84%) and normal myocardium (from 200 ±25 to 321 ±38 ml min–1 100 g–1) as well as infarcted myocardium (from 41 ±8 to 61 ±19 ml min–1 100 g–1) increased significantly. The largest fraction of the increase in cardiac output was, however, used for the improvement of skeletal muscle blood flow (from 13 ±5 to 62±13 ml min–1 100 g–1). It is concluded that nisoldipine increases cardiac output in conscious pigs with heart failure, primarily by decreasing peripheral vascular resistance. The increment in cardiac output is distributed preferentially to the skeletal muscles.

Key Words: Heart failure • myocardial infarction • systemic haemodynamics • regional blood flows • coronary collateral flow • nisoldipine • pigs


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.