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European Heart Journal 1990 11(9):788-790;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Early appearance of 2, 3-butanediol in acute myocardial infarction. A new marker for ischaemia?

K. R. HEER, H. STALDER and H. THOELEN

Department Forschung Kantonsspital Basel, and Medizinische Abteilung Kantonsspital Liestal Switzerland

Received 1 November 1988; revised 24 November 1989; .

Address for corespondence K. R. Heer, Kasernenstrasse 22A, 4410 Liestal, Switzerland

Abstract

In 28 patients with acute myocardial infarction, the release pattern of 2, 3-butanediol (BD), a product of intermediary metabolism, and creatine kinase activity (CK) in blood were compared. Whereas CKat entry was low in all patients, the BD level was elevated in 18 (64%). However, BD returned to normal levels during the next 24 h whereas CK increased. The BD level at entry did not allow differentiation between patients with transmural or non-transmural infarction; it was independent of clinical findings and biochemical parameters. We suggest that, in patients with acute myocardial infarction, elevated levels of BD originates from myo-cardial metabolism. Whether it reflects ongoing ischaemia or reperfusion of the infarcted area remains unresolved.

Key Words: Acute myocardial infarction • 2, 3-butanediol • ischaemia


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