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European Heart Journal 1990 11(9):814-818;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Increased neutrophil aggregability in coronary artery disease

G. RICEVUTI, S. DE SERVI*,, A. MAZZONE, L. ANGOLI*, S. GHIO* and G. SPECCHIA*

Department of Internal Medicine and Therapeutics Section of Medical Pathology
*Division of Cardiology University of Pavia IRCCS, S. Matteo Hospital, Pavia, Italy

Received 19 June 1989; revised 2 January 1990; .

Address for reprints: Stefano De Servi M. D., Division of Cardiology, IRCCSS. Matteo Hospital, 27100 Pavia, Italy.

Abstract

The purpose of this investigation was to study neutrophil (PMN) aggregation in the aorta and coronary sinus of 20 patients with angiographically documented coronary artery disease (group I) compared with eight patients with normal coronary arteries (group II). PMNs were separated from the other blood components and their aggregation response to Ca2+ ionophore A 23187 1 x 10–5 M (final concentration) was measured.

Group I patients had higher aggregating activity in the coronary sinus than in the aorta (24.9± 3.7 vs 18.7± 3.4 average maximum {Delta}T, P<0.01), while no difference was found in group II (coronary sinus 16.7±3.5; aorta 16.3±2.4 average maximum {Delta}TP = NS). Among group I patients, smokers had a significantly higher aggregating activity than non-smokers, whereas no correlation was found between aggregation response and blood cholesterol values.

These data suggest that the presence of atherosclerotic plaques in coronary vessels may prime PMNs so that they show greater aggregating response to subsequent stimulation.

Key Words: Neutrophil • aggregation • coronary artery disease


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