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European Heart Journal 1990 11(Supplement A):48-49; doi:10.1093/eurheartj/11.suppl_A.48
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Acute haemodynamic effects of the β1-adrenoceptor partial agonist xamoterol at rest and during supine exercise in patients with left ventricular dysfunction due to ischaemic heart disease: a double-blind randomized trial

P. J. de Feyter and P. W. Serruys

Thoraxcentre, Erasmus University Rotterdam, The Netherlands

The effects of xamoterol 0·2 mg kg–1 i.v. and placebo on left ventricular function at rest and on exercise were compared in patients with left ventricular dysfunction due to ischaermic heart disease. Improvements were seen in systolic and diastolic function at rest, and at up to 50% of maximal exercise, without evidence of worsening myocardial ischaemia.


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