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European Heart Journal 1990 11(Supplement A):54-55; doi:10.1093/eurheartj/11.suppl_A.54
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Selectivity of xamoterol, prenalterol and salbutamol as assessed by their effects in the presence and absence of ICI 118 551

P. M. McCaffrey, J. G. Riddell and R. G. Shanks

Department of Therapeutics and Pharmacology, The Queen's University of Belfast Belfast, U.K.

Selectivity for β1- and β2-receptors to xamoterol, prenalterol and salbutamol were tested using ICI 118 551, a specific β2-receptor antagonist. Measurements were made of heart rate at rest and exercise, blood pressure, forearm blood flow and finger tremor. The actions of xamoterol were similar to those previously demonstrated, and were unaffected by β2-blockade, indicating selectivity for the β1-receptor. Salbutamol was selective for the β2-receptor and prenalterol was active at both.


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