Skip Navigation

European Heart Journal 1990 11(Supplement B):133-138; doi:10.1093/eurheartj/11.suppl_B.133
Copyright © 1990 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Vogt, M.
Right arrow Articles by Strauer, B. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vogt, M.
Right arrow Articles by Strauer, B. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 The European Society of Cardiology

Coronary microangiopathy and cardiac hypertrophy

M. Vogt, W. Motz, B. Schwartzkopff and B. E. Strauer

Medizinische Klinik and Poliklinik B, University of Düsseldorf F.R.G.

Correspondence: Martin Vogt MD, Medizinische Klinik und Poliklinik B, Universität Düsseldorf, Abteilung für Kardiologie, Pneumologie und Angiologie, Moorenstrasse 5, D-4000 Düsseldorf 1, West Germany

Even in the absence of coronary heart disease, coronary vasodilator reserve is frequently impaired in hypertensive patients. To study, whether the reduced coronary reserve is due to the degree of left ventricular hypertrophy or is a consequence of primary vascular alterations, coronary reserve was determined in 54 hypertensiue patients with angina pectoris and angiographically normal coronary arteries. Twelve normotensive persons were studied for control purposes. Coronary blood flow was measured quantitatively by the gas chromatographic argon method. Coronary reserve was determined by measuring coronary resistance before and after dipyridamole (0·5 mg (kg body weight)–1 i.v.). Left ventricular muscle mass was determined by ventriculography. In hypertensive patients, minimal coronary resistance was markedly increased by 124% and coronary reserve signfiantly reduced by about 38% compared with healthy normotensives. Hypertensives and normotensives did not differ with respect to myocardial oxgyen consumption per unit weight myocardrum (11·9 ± 2·3 vs 11·4 ± 2·4 ml O2 100g–1 min, n.s.) and resting coronary pow (92·1 ± 20·8 vs 91·4 ± l8·9 ml min–1 min, n.s.). No significant correlation was found between minimal coronary resistance and coronary reserve and left ventricular murcle mass and between coronary reserve and diastolic wall stress. Accordingly, the reduced coronary regulation capacity in hypertensives does not parallel the degree of left ventricular hypertrophy and is not due to an increased myocardial oxygen consumption under resting conditions. Consequently, the impaired coronary reserve in hypertensive patients seems to be the consequence of primary microvascular lesions, which are independent of the process of left ventricular hypertrophy.

Key Words: arterial hypertension • coronary reserve • left ventricular hypertrophy • microvascular angina pectoris • media hypertrophy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.