Skip Navigation

European Heart Journal 1990 11(Supplement B):35-42; doi:10.1093/eurheartj/11.suppl_B.35
Copyright © 1990 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pohl, U.
Right arrow Articles by Busse, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pohl, U.
Right arrow Articles by Busse, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 The European Society of Cardiology

Endothelium-dependent modulation of vascular tone and platelet function

U. Pohl and R. Busse

Institute of Applied Physiology, University of Freiburg F.R.G.

Address for correspondence: Dr Ulrich Pohl, Inst. of Applied Physiology, Hermann-Herder-Straβe 7, D-7800 Freiburg, F.R.G.

Endothelial cells exert potent effects on vascular tone and platelet activity by the release of autacoids. One of the functionally most important autacoids is the endothelium-derived relaxant factor (EDRF). It inhibits platelet and vascular smooth muscle activation by cGMP-dependent attenuation of the agonist-induced rise of intracellular free Ca2+. Recent experiments suggest that EDRF has a physiologic role in the control of the vascular tone of large arteries and resistance vessels. Furthermore, there is evidence that an impairment of EDRF release may be a significant pathophysiologic factor in myocardial ischaemia. Coronary vascular tone might be also affected by the endothelium-derived vasoconstrictor peptide, endothelin, but its significance for the control of coronary blood flow remains to be elucidateded.

Key Words: Endothelium-derived relaxant factor (EDRF) • endothelin • platelets • cyclic GMP • antiaggregation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.