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European Heart Journal 1990 11(Supplement B):53-57; doi:10.1093/eurheartj/11.suppl_B.53
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Coronary arteriolar vasoconstriction in myocardial ischaemia. Vasopressin, renin–angiotensin system and ANF

G. Ertl and B. Bauer

Medizinische Klinik, Universität Würzburg West Germany

Address for correspondence: PD Dr G. Ertl, Medizinische Klinik, Universität Würzburg, Josef-Schneider-Str 2, D-8700 Würzburg, F.R.G.

Vasopressin, the renin-angiotensin system and atrial natriuretic factor (ANF) interact in regulating blood pressure. While the vasoconstrictor effect of vasopressin and the renin-angiotensin system is well documented, the direct vascular effect of ANF is unclear. We studied in anaesthetized dogs the coronary vascular effects of agonists and antagonists of vasopressin and the renin-angiotensin system under control and ischaemic conditions, respectively. In addition, the action of ANF and its relationship to the renin-angiotensin system was analysed. A coronary artery was cannulated and perfused by a bypass system from the femoral arteries of the same animal. Coronary vasoconstriction by vasopressin was potentiated when myocardial ischaemia was induced by lowering coronary petfusion pressure while coronary constriction by angiotension I and II was mitigated. A vasopressin receptor blocker slightly reduced coronary blood flow at high doses (intrinsic activity) while the angiotensin II receptor blocker increased coronary flow in myocardial ischaemia. ANF effects were ambiguous at lower doses (1 ng (kg)–1 i.c.) with coronary constriction in 79% of dogs. At higher doses (1 µg kg–1) ANF consistently induced coronary dilation. The angiotensin II receptor blocker saralasin signrficantly reduced this coronary dilator effect of ANF. Thus, in conclusion, a vasoconstrictor effect of endogenous vasopressin could not be shown by this study. In contrast, endogenous angiotensin II might participate in control of coronary blood flow during myocardial ischaemia. The coronary dilator effect of ANF at least in part appears to be due to interference with the renin-angiotensin system.

Key Words: Vasoconsriction • coronary circulaion ischaemia • vasopression • angiotensin II


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