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European Heart Journal 1990 11(Supplement E):116-121; doi:10.1093/eurheartj/11.suppl_E.116
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Macrophages and ceroid in human atherosclerosis

M. J. Mitchinson, R. Y. Ball, K. L. H. Carpenter and J. H. Enright

Division of Cellular and Genetic Pathology, Cambridge University Department of Pathology Cambridge, England

Address for correspondence: M. J. Mitchinson, Division of Cellular and Genetic Pathology, Cambridge University Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK

It is proposed that atherosclerosis is a chronic inflammatory disease in which monocyte-derived macrophages are doing harm and smooth muscle cells are essentially reparative. Activities of macrophages that might be contributory to the development of atherosclerosis are tabulated. Observations and experiments are described that suggest macrophages may be contributing to lipoprotein oxidation within the plaque and that individual humans vary in their macrophage oxidative capacity. The possibility of intervention with antioxidants is discussed.

Key Words: Atherosclerosis • monocytes • macrophages • lipid oxidation


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