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European Heart Journal 1990 11(Supplement E):190-195; doi:10.1093/eurheartj/11.suppl_E.190
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Interaction of lipoprotein(a) with fibronectin and its potential role in atherogenesis

C. Ehnholm, M. Jauhiainen and J. Metso

National Public Health Institute Helsinki, Finland

Address for correspondence: Dr Christian Ehnholm, National Public Health Institute, Mannerheimintie 166, SF-00300 Helsinki, Finland

The plasma concentration of lipoprotein (a) (Lp(a)) varies widely in humans, and elevated concentrations of this lipoprotein are correlated with progression of atherosclerosis. Structural studies of Lp(a) have revealed that it is a low density lipoprotein (LDL)-like particle containing a unique glycoprotein, apo(a), which shares extensive homology wirh plasminogen. The apo(a) portion of Lp(a) binds to the carboxy-terminal heparinbinding domain of fibronectin. Incubation of Lp(a) or isolated apo(a) with fibronectin results in proteolytic cleavage of fibronectin which is, as visualized by gel electrophoresis and immunoblotting, distinct from that caused by plasmin or kallikrein. The proteolytic activity of apo(a) is of serine proteinare-type and displays specificity for arginine rather than lysine bonds. The molecular mechanism(s) underlying the association between Lp(a) and atherosclerosis remains an enigma.

Key Words: Lp(a) • fibronectin • proteolysis • atherosclerosis


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