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European Heart Journal 1990 11(Supplement E):218-224; doi:10.1093/eurheartj/11.suppl_E.218
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Initial steps in reverse cholesterol transport: the role of short-lived cholesterol acceptors

O. L. Francone and C. J. Fielding*

Cardiovascular Research Institute, University of California Medical Centre San Francisco, U.S.A.
* Department of Physiology, University of California Medical Centre San Francisco, U.S.A.

Address for correspondence: C. J. Fielding, Department of Physiology, University of California Medical Center, San Francisco, CA 94143, USA

The early metabolism of cell-derived cholesterol was followed during the interaction of normolipaemic native plasma with cultured cell monolayers labelled to high specific activity with 3H-cholesterol. Kinetic analysis indicated that initial processing involved several prebeta-migrating high-density lipoprotein (HDL) species. A small prebeta species, the initial acceptor, was first converted to a lipoprotein whose composition predicts a discoidal structure. The free cholesterol content of this war then esterified by lecithin: cholesterol acyltransferase, and its cholesterol converted to the alpha mobility of spheroidal mature HDL the binding of apolipoprotein A-II. These studies follow the genesis of HDL in plasma from peripheral cell membrane cholesterol.

Key Words: Plasma cholesterol transport • high density lipoprotein • lecithin: cholesterol acyltransferase


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