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European Heart Journal 1990 11(Supplement E):53-60; doi:10.1093/eurheartj/11.suppl_E.53
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Intimal thickening in the coronary arteries of infants and children as an indicator of risk factors for coronary heart disease

E. Pesonen*,, R. Norio{dagger}, J. Hirvonen||, K. Karkola{ddagger}, V. Kuusela§, H. Laaksonen, M. Möttönen**,1, T. Nikkari{dagger}{dagger}, J. Raekallio,1, J. Viikari{ddagger}{ddagger}, S. Ylä-Herttuala{dagger}{dagger} and H. K. Åkerblom§§

* The Children's Hospital, I, Department of Pediatrics, University of Helsinki
{dagger} Department of Medical Genetics, Väestöliitto (The Finnish Population and Family Welfare Federation
|| Departments of Forensic Medicine, University of Oulu
{ddagger} Department of Forensic Medicine, University of Kuopio
§ Central Statistical Office of Finland
Department of Forensic Medicine, University of Turku
** Department of Forensic Medicine, University of Helsinki
{dagger}{dagger} Department of Biomedical Sciences, University of Tampere
{ddagger}{ddagger} Department of Internal Medicine, University of Turku
§§ The Children's Hospital, II, Department of Pediatrics, University of Helsinki

Address for correspondence: Erkki Pesonen, M.D., The Children's Hospital, University of Helsinki, Stenbäckikatu 11, SF-00290 Helsinki, Finland

Narrowings of the coronary arteries were measured in 94 infants aged < 1 year who died in hospital and 102 1- to 16-year-old children who died accidentally. The arteries were transformed mathematically to circles. The degree of narrowing camed by intimal thickening was determined as the ratio of intimal area to the original luminal area. This ratio was further transformed to percentage.

The degree of narrowing varied between 0 and 58% (mean 20%). The mean degree of narrowing in the left coronary artery during the first year of life was 177% and, between 12 and 15 years, 34%. Narrowing was greater in males (P = 0·02), when all the 333 coronary samples were included in the analysis.

The birthplaces, the subjects’ grandparents were traced from population registers and it was found that narrowing in the left coronary artery of infants was greater in those descended from grandparents from eastern Finland, an area of high mortality from coronary heart disease (CHD). Intimal thickening in infants and children seems to be a morphological manifestation of hereditary predisposition to CHD.

Key Words: Intimal thickening • coronary arteries • coronary heart disease • genetics • infants • children

1 Deceased.


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