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European Heart Journal 1990 11(Supplement G):17-23; doi:10.1093/eurheartj/11.suppl_G.17
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Physical properties of the aorta and cardiac hypertrophy in essential hypertension

B. M. Pannier, G. M. London, J.-L. Cuche, X. Girerd and M. E. Safar

Department of Internal Medicine and the Hypertension Research Center and INSERM (CJF 89-02), Broussais Hospital Paris, France

Correspondence: Professor Michel Safar, Service de Medecine 1, Hospital Broussais, 96, rue Didot, 75674 - Paris, France

The load of the heart in hypertension is related not only to increased peripheral vascular resistance but also to decreased aortic compliance. From non-invasive clinical studies involving determinations of pulse wave velocity and systolic-diastolic variations of aortic arch diameter, it can be shown that decreased aortic compliance is strongly related to increased cardiac mass. The correlation is observed even after adjustment for the level of blood pressure. It is suggested that decreased aortic compliance in hypertension causes a disproportionate increase in systolic pressure and end-systolic stress, thus contributing to promote cardiac hypertrophy with possible consequences for epidemiology, clinical investigation and treatment.

Key Words: Essential hypertension • aortic compliance • cardiac hypertrophy


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