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European Heart Journal 1990 11(Supplement H):38-43; doi:10.1093/eurheartj/11.suppl_H.38
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

The triglyceride controversy: a review of the data

P. Schwandt

University of Munich Munich, F.R.G.

Address for correspondance: Professor Dr med Peter Schwandt, Department of Medicine II, University of Munich, Marchioninistrasse 15,8000 Munich 70, F.R.G.

Although some studies indicate that elevated triglyceride levels are an independent risk factorfor coronary heart disease (CHD), the significance of hypertriglyceridaemia in atherosclerosis and CHD remains controversial. While many epidemiologic case-control studies show a significant association between triglycerides levels and CHD, these studies do not consider other variables that may affect the significance of triglycerides in their analysis of the data (e.g. triglycerides and high density lipoprozeins). The absence of a consensus on the role of elevated triglycerides is balanced by the flaws in the currently available statistical approaches to analysing triglyceride levels. An association between hypertriglyceridaemia and abnormally high concentrations of apolipoprotein (apo) B has also been observed. Some researchers suggest that apo B is a better predictor of angiographically proven coronary atherosclerosis than total cholesterol or low density lipoprotein cholesterol and triglycerides. Although no consensus yet exists on the triglyceride question, available data strongly suggest that triglycerides warrant serious consideration.

Key Words: Coronary heart disease • high density lopoproteins • low density lopoproteins • viry low density lopoproteins • serum lipids • triglycerides


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