Copyright © 1991 by the European Society of Cardiology.
© 1991 The European Society of Cardiology
Catecholamines and thrombocyte 
2-adrenoceptors in patients with acute myocardial infarction
Center of Internal Medicine (Medizinische Klinik I und ll), Justus- Liebig- University Giessen
*Kerckhoff- Clinic, Bad Nauheim Germany
Received 29 November 1988; revised 5 April 1990; .
Correspondence to: Dr Friedrich L
bbecke. Zentrum fü r Innere Medizin, Klinikstrafle 36, D-6300 Gieflen, Germany.
Abstract
In 28 patients with first myocardial infarction plasma catecholamines and thrombocyte alpha2-adrenoceptors were studied. The first determination (by HPLC and radioligand binding, respectively) was performed immediately after hospital admission and 6 weeks later. In the acute phase of myocardial infarction plasma adrenaline and noradrenaline levels were high. No significant differences in thrombocyte alpha2-adrenoceptors and plasma concentrations of adrenaline and noradrenaline were observed between diabetic and non-diabetic patients. In three non-surviving patients only the affinity of the alpha2-adrenoceptor to the radioligand was decreased (P < 0.05), the relatively high catecholamine levels failed to reach statistical significance. Six weeks after hospital admission, adrenaline plasma levels were significantly decreased in diabetic and non-diabetic patients, while noradrenaline was only lowered in non-diabetic patients (P < 0.05). Only in this group did the receptor number (BMAX) show a significant elevation 6 weeks after hospital admission. We conclude that, in acute myocardial infarction, alpha2-adrenoceptors mainly interact with noradrenaline. Accordingly, no adrenoceptor alteration occurred in diabetic patients, who showed only a decrease in adrenaline but not in noradrenaline plasma concentrations 6 weeks following myocardial infarction. The different patterns in diabetic and non-diabetic patients suggest an alteration of catecholamine metabolism in diabetes mellitus.
Key Words: Alpha-adrenoceptors • catecholamines • diabetes mellitus • myocardial infarction • thrombocytes
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