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European Heart Journal 1991 12(10):1084-1088;
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Coronary artery thrombosis and thrombolysis in baboons: the effect of atenolol treatment on myocardial infarct size

P. HERIJGERS and W. FLAMENG

Department of Cardiology, Aalborg Hospital South Aalborg, Denmark

Received 8 May 1990; revised 1 October 1990; .

Correspondence: Prof Dr Willem Flameng, Center of Experimental Surgery and Anesthesiology (CEHA). Katholieke Universiteit Leuven. Provisonum I. Minderbroedersstraat 17. 3000 Leusen. Belgium

Abstract

The effect of the beta-blocker atenolol on experimental infarct size was studied in a non-human primate model. In 12 baboons thrombosis of the left anterior descending coronary artery (LAD) was induced and atenolol (0·1 to 0·2 mg . kg–1 intravenously, sufficient to lower the heart rate by 20%) was administered 10 mm after the onset of ischaemia in six animals, whereas the others received placebo. Thrombolysis was induced 60 mm after the onset of ischaemia by intravenous injection of rt PA (12 µg. kg–1. min–1) in all animals.

Heart rate dropped signficantly after atenolol injection (128±9 beats . min–1 versus 163±15 beats . min–1, P<0001) and was also lower than in the control group (128±9 beats. min–1 versus 158±22 beats.min–1, p<0·05). Blood pressure remained unchanged after atenolol treatment. As compared to the control group, atenolol limited infarct size, expressed as a percentage of left ventricular mass (4·6±1·9% versus 7·9±1·3%, P<0·05 or as a percentage of the perfusion area (26±8% versus 43%8%, P<0·05).

Key Words: Experimental myocardial infarction • baboons • infarct size reduction • beta-adrenergic receptor blocking agents


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