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European Heart Journal 1991 12(10):1132-1139;
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Left ventricular flow from apex to base during systole and isovolumic relaxation in a patient with hypertrophic cardiomyopathy and midventricular obstruction

G. SÜTSCH, R. JENNI and H. P. KRAYENBÜHL

From the Department of Internal Medicine, Medical Policlinic, Cardiology, University Hospital Zürich Switzerland

Received 11 September 1990; revised 29 November 1990; .

Correspondence: Dr G. Sütsch, MD. Department of Internal Medicine. Medical Po$$$cnic. Cardiology University Hospital Rämistrasse 100, CH-8091 Zürich, Switzerland

Abstract

The occurrence of a left ventricular anterograde flow velocity (maximal: 3·9m . s–1) is demonstrated in a 32-year-old patient with hypertrophic cardioinyopathy and midveniricular obstruction, beginning at early systole and persisting throughout the isovolumic relaxation. Cardiac catheterization with simultaneous dual high fidelity pressure measurements in the apical and basal chambers confirmed the presence of the Doppler maximal instantaneous pressure gradient of 60 mmHg. Contrast left ventricular angiography excluded apical dyskinesia. In the two intracavity compartments, isovolumic relaxation time and the time constant of pressure decay ({tau}) were abnormal whereby {tau} was more delayed in the apical than in the basal portion. The presence of an apical high pressure zone during systole with impeded and delayed emptying through the midventricular obstacle and the late onset and prolongation of relaxation are thought to be the cause of the intraventricular flow from apex to base lasting from early systole throughout isovolumic relaxation.

Key Words: Cardiomyopathy with midventricular obstruction • Doppler and isovolumic relaxation flow


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