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European Heart Journal 1991 12(10):1144-1147;
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Sudden cardiac death while taking amiodarone therapy: the role of abnormal repolarization

J. M. MORGAN*, A. LOPES{dagger} and E. ROWLAND{ddagger}

National Heart and Chest Hospitals, Brompton Hospital London S W3 6HP, U.K.

Received 12 April 1990; revised 7 August 1990; .

Correspondence: Dr J. M. Morgan, Cardiac Department. Brompton Hospital, London SW3 6HP, U.K.

Abstract

Torsade depointes may occur as a complication of amiodarone therapy. We report a patient receiving amiodarone who was resuscitated from cardiovascular collapse and documented ventricular fibrillation. At subsequent electrophysiology study, while the patient was taking amiodarone therapy, monophasic action potentials with early after depolarisations were recorded which were not present when the patient was restudied 6 weeks after discontinuation of amiodarone. Early after-depolarisations may be important in the genesis of polymorphic ventricular tachycardia complicating amiodarone therapy.

Key Words: Early after-depolarisations • polymorphic ventricular tachycardia • amiodarone


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