Copyright © 1991 by the European Society of Cardiology.
© 1991 The European Society of Cardiology
Tissue plasminogen activator and other risk factors as predictors of cardiovascular events in patients with severe angina pectoris
*Department of Internal Medicine, Skellefte{acute} Hospital Sweden
Departments of Clinical Chemistry, Umeá University Hospital Sweden
Departments of Internal Medicine, Umeá University Hospital Sweden
Received 13 December 1989; revised 26 March 1990; .
Correspondence: Dr Jan-H{dot}kin Jansson, Department of Internal Medicine, Skellefle{dot}Hospital, S-93186 Sweden.
Abstract
The value of measurements of the fibrinolytic factors, tissue plasminogen activator and plasminogen activator inhibitor, for predicting death and non-fatal cardiovascular events was studied in 213 consecutive patients with angiographically documented coronary artery disease. In the course of 4-year follow-up, 47 patients (22.1%) had at least one cardiovascular event. We found the incidence of cardiovascular events to be positively associated with high tissue plasminogen activator antigen concentration, in addition to previous myocardial infarction, low ejection fraction, hypertension, high body mass index and high triglyceride levels. Cholesterol was not found to be associated with cardiovascular events. A high concentration of tissue plasminogen activator antigen thus implies an increased risk of cardiovascular events in patients with severe angina pectoris.
Key Words: coronary artery disease • risk factors • fibrinolysis • tissue plasminogen activator • plasminogen activator inhibitor
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