Copyright © 1991 by the European Society of Cardiology.
© 1991 The European Society of Cardiology
Reduction in QT dispersion by sotalol following myocardial infarction
Department of Academic Cardiology, Freeman Hospital, Newcastle upon Tyne U.K.
*Department of Medical Statistics, Medical School, University of Newcastle upon Tyne U.K.
Received 27 November 1989; revised 24 April 1990; .
Correspondence and reprint requests to: Dr C. P. Day, Research Fellow, Dept of Medicine, Medical School, University of Newcastle upon Tyne, U.K.
Abstract
Increased dispersion of ventricular recovery time is believed to be a substrate for serious ventricular arrhythmias. Class III antiarrhythmic drugs probably operate by decreasing dispersion through homogeneous prolongation of recovery time. A single surface QT value gives no information on recovery time dispersion but interlead variation in QT may be relevant. QTc dispersion was measured in 67 patients post myocardial infarction randomized to treatment with either sotalol or placebo. QTc dispersion was calculated as the difference between the maximum and minimum QTc in any surface electrocardiogram lead. Both maximum QTc and QTc dispersion varied considerably following infarction but throughout the 6-month follow-up period maximum QTc was significantly greater (P<0.05) and QTc dispersion significantly less (P < 0.05) in patients on sotalol compared with placebo. These findings are in accord with expected changes in ventricular recovery time and provide strong support for the hypothesis that surface electrocardiogram QT variation reflects regional differences in ventricular recovery time
Key Words: Myocardial infarction • sotalol • QT interval • QT dispersion
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Dursunoglu, N. Dursunoglu, H. Evrengul, S. Ozkurt, M. Kilic, F. Fisekci, O. Kuru, and O. Delen QT interval dispersion in obstructive sleep apnoea syndrome patients without hypertension Eur. Respir. J., April 1, 2005; 25(4): 677 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kumar, M. Fisher, and P. W Macfarlane Review: Diabetes and the QT interval: time for debate The British Journal of Diabetes & Vascular Disease, May 1, 2004; 4(3): 146 - 150. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Kabakci, O. Onalan, M. Kemal Batur, A. Yildirir, R. Cagrikul, T. Acil, L. Tokgozoglu, A. Oto, F. Ozmen, and S. Kes What is the Optimal Evaluation Time of the QT Dispersion After Acute Myocardial Infarction for the Risk Stratification? Angiology, July 1, 2001; 52(7): 463 - 468. [Abstract] [PDF]
|
|
|
|
 |
|
 K.-M. Yee, S. D. Pringle, and A. D. Struthers Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1800 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Yetkin, K. Senen, M. Ileri, R. Atak, S. Topaloglu, K. Ergun, A. Yanik, I. Tandogan, S. Cehreli, E. Duru, et al. Diurnal Variation of QT Dispersion in Patients With and Without Coronary Artery Disease Angiology, May 1, 2001; 52(5): 311 - 316. [Abstract] [PDF]
|
|
|
|
|
|
H. Tikiz, T. Terzi, Y. Balbay, A. D. Demir, M. Soylu, T. Keles, and E. Kutuk QT Dispersion in Single Coronary Artery Disease: Is There a Relation Between QT Dispersion and Diseased Coronary Artery or Lesion Localization? Angiology, January 1, 2001; 52(1): 43 - 51. [Abstract] [PDF]
|
|
|
|
|
|
M. Malik and V. N. Batchvarov Measurement, interpretation and clinical potential of QT dispersion J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1749 - 1766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sahu, P.O. Lim, B.S. Rana, and A.D. Struthers QT dispersion in medicine: electrophysiological Holy Grail or fool's gold? QJM, July 1, 2000; 93(7): 425 - 431. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Houltz, B. Darpo, K. Swedberg, P. Blomstrom, H.J.G.M. Crijns, S.M. Jensen, E. Svernhage, and N. Edvardsson Comparison of QT dispersion during atrial fibrillation and sinus rhythm in the same patients, at normal and prolonged ventricular repolarization Europace, January 1, 2000; 2(1): 20 - 31. [Abstract] [PDF]
|
|
|
|
|
|
S. Paventi, U. Bevilacqua, M. A. Parafati, E. Di Luzio, F. Rossi, P. R. Pelliccioni, and S. Paventi QT Dispersion and Early Arrhythmic Risk During Acute Myocardial Infarction Angiology, March 1, 1999; 50(3): 209 - 215. [Abstract] [PDF]
|
|
|
|
 |
|
 C E Bonnar, A P Davie, L Caruana, L Fenn, S A Ogston, J J V McMurray, and A D Struthers QT dispersion in patients with chronic heart failure: beta blockers are associated with a reduction in QT dispersion Heart, March 1, 1999; 81(3): 297 - 302. [Abstract] [Full Text]
|
|
|
|
|
|
L. J. L. M. Jordaens The clinical value of QTdispersion: new perspectives on the assessment of cardiac repolarization more than 75 years after Bazett's formula Europace, January 1, 1999; 1(2): 73 - 76. [PDF]
|
|
|
|
|
|
J A Kors and G van Herpen Measurement error as a source of QT dispersion: a computerised analysis Heart, November 1, 1998; 80(5): 453 - 458. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. C. de Bruyne, A. W. Hoes, J. A. Kors, A. Hofman, J. H. van Bemmel, and D. E. Grobbee QTc Dispersion Predicts Cardiac Mortality in the Elderly : The Rotterdam Study Circulation, February 10, 1998; 97(5): 467 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Gatzoulis, J. A. Till, and A. N. Redington Depolarization-Repolarization Inhomogeneity After Repair of Tetralogy of Fallot: The Substrate for Malignant Ventricular Tachycardia? Circulation, January 21, 1997; 95(2): 401 - 404. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. C. Deedwania Sotalol Is More Powerful Than Propranolol in Suppressing Complex Ventricular Arrhythmias Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1997; 2(4): 259 - 272. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Mayet, M. Shahi, K. McGrath, N. R. Poulter, P. S. Sever, R. A. Foale, and S. A. McG. Thom Left Ventricular Hypertrophy and QT Dispersion in Hypertension Hypertension, November 1, 1996; 28(5): 791 - 796. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. J Linker and A. P Fitzpatrick QTc dispersion and risk of cardiac death in peripheral vascular disease BMJ, October 26, 1996; 313(7064): 1081c - 1081. [Full Text]
|
|
|
|
|
|
J.-L. Demolis, C. Funck-Brentano, J. Ropers, M. Ghadanfar, D. J. Nichols, and P. Jaillon Influence of Dofetilide on QT-Interval Duration and Dispersion at Various Heart Rates During Exercise in Humans Circulation, October 1, 1996; 94(7): 1592 - 1599. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Perkiomaki, M. J. Ikaheimo, S. M. Pikkujamsa, A. Rantala, M. Lilja, Y. A. Kesaniemi, and H. V. Huikuri Dispersion of the QT Interval and Autonomic Modulation of Heart Rate in Hypertensive Men With and Without Left Ventricular Hypertrophy Hypertension, July 1, 1996; 28(1): 16 - 21. [Abstract] [Full Text]
|
|