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European Heart Journal 1991 12(3):434-438;
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Prolonged hypotensive effect of OPC-13340: a new, once-daily calcium channel blocking drug

P. BROADHURST, G. BRIGDEN, N. HITTEL, A. LAHIRI and E. B. RAFTERY

Department of Cardiology, Northwick Park Hospital and Clinical Research Centre Watford Road, Harrow HA13UJ, U.K.

Received 29 December 1989; revised 8 May 1990; .

Correspondence: Edward B. Raftery, MD, Department of Cardiology and Division of Cardiovascular Diseases, Northwick Park Hospital and Clinical Research Centre, Watford Road, Harrow HA1 3UJ, U.K.

Abstract

The duration and magnitude of the hypotensive effect of a new, once daily dihydropyridine calcium channel blocking drug, OPC-13340, was assessed in 14 patients with essential hypertension during normal daily activities and programmed exercise testing. Intra-arterial ambulatory blood pressure (BP) monitoring was performed before and after one month's treatment. Mean reduction in day-time BP was 27/14mmHg and night-time BP 18/11 mmHg (P<0.001 and 0.05 respectively). There was no change in heart rate throughout the 24 h. Satisfactory day-time control of systolic and diastolic BP using the drug as monotherapy was achieved in 58% and 88% of patients respectively, although adequate control of nocturnal systolic and diastolic BP occurred in only 54% and 50% of patients respectively. No postural hypotension occurred during tilt testing, and there was a significant reduction in the peak BP observed during both dynamic and isometric exercise. Side effects were mild and transient. Thus OPC-13340, given once daily, is an effective and well tolerated anti-hypertensive drug, with a prolonged 24-h action.

Key Words: OPC-13340 • calcium antagonists • hypertension • ambulatory blood pressure


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