Copyright © 1991 by the European Society of Cardiology.
© 1991 The European Society of Cardiology
Microalbuminuria is an early response following acute myocardial infarction
*Department of Biochemistry, Selly Oak Hospital Birmingham B29 6JD, U.K
Departments of Clinical Chemistry and Cardiology, East Birmingham Hospital Birmingham B9 5ST, U.K
Received 27 April 1990; revised 25 June 1990; .
Correspondence. Dr Gosling, Biochemistry Department. Selly Oak Hospital. Birmingham B29 6LX, U.K.
Abstract
Ninety-six patients admitted to two coronary care units with suspected acute myocardial infarction were studied. The diagnosis was confirmed in 44, the remaining 52 were used as a control group. The first urine passed after admission, together with early morning urines on the following 3 days, were saved in all patients. Urinary albumin and IgG were measured by automated immunoturbidimetry and expressed as the protein creatinine ratio in mg.mmol–1. The log mean (SD) albumin creatinine ratios for the first urine passed in the myocardial infarction and non-myocardial infarction patient groups were 6.2(4.2) and 1.3(3.4) respectively. The difference in log mean albumin creatinine ratio was 4–9 mg.mmol–1, 95% CI3.4 to 6.2 mg.mmol–1 t=6.127 df=94, P<0.0001. The median IgG creatinine ratio for the first urine passed after admission in myocardial infarction patients was 1.0 mg.mmol–1 (95% Cl 0.5 to 1.2) and for non-myocardial infarction patients 0.3 (95% Cl 0.2 to 0.4). Increased urinary protein excretion appears to be an early and proportional response to acute myocardial infarction.
Key Words: Albuminuria • myocardial infarction • aspartate aminotransferase • capillary permeability
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