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European Heart Journal 1991 12(5):563-572;
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Ventricular late potentials in patients with and without inducible sustained ventricular tachycardia: a combined analysis in the time and frequency domain

J. SCHRAMM, C. FRUMENTO, H. DICKHAUS, C. SCHMITT and J. BRACHMANN

Medizinische Universitätsklinik (Department of Cardiology) and Department of Medical Informatics, University of Heidelberg Germany

Received 5 September 1989; revised 26 July 1990; .

Correspondence to: Dr Joachim Schramm, Blücherstr. 3, 6900 Heidelberg, Germany

Abstract

Time and frequency of signal-averaged electrocardiograms from 51 patients and 19 normal subjects were studied. A new filter device was designed to facilitate the analysis of the complete QRS complex, particularly the high-frequency components. All patients underwent electrical programmed stimulation (EPS) with up to three extra stimuli. In 29 patients, sustained ventricular tachycardia (VT) was inducible (group A), whereas in 22, sustained VT could not be elicited (group B). Between A and B, we compared several variables from the signal-averaged ECG as well as clinical data. The variables that differed between the two groups (P<0·01 were entered into a logistic regression model to determine which ones could most reliably predict the outcome of EPS.

A combination of three variables (number of minima and maxima in the terminal QRS; third of four areas of equal length, divided by the total area below the QRS; maximum of the frequency spectre in the terminal QRS) could predict the inducibility of sustained VT with 82·8% sensitivity and 86·4% specifity.

Key Words: Ventricular late potentials • sustained ventricular tachycardia • Fourier transform • programmed stimulation


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