Skip Navigation

European Heart Journal 1991 12(6):1084-1088;
Copyright © 1991 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by HERIJGERS, P.
Right arrow Articles by FLAMENG, W.
Right arrow Search for Related Content
PubMed
Right arrow Articles by HERIJGERS, P.
Right arrow Articles by FLAMENG, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1991 The European Society of Cardiology

Coronary artery thrombosis and thrombolysis in baboons: the effect of atenolol treatment on myocardial infarct size

P. HERIJGERS and W. FLAMENG

Department of Cardiology, Aalborg Hospital South Aalborg, Denmark

Received 8 May 1990; revised 1 October 1990; .

Correspondence: Prof Dr Willem Flameng, Center of Experimental Surgery and Anesthesiology (CEHA). Katholieke Universiteit Leuven. Provisonum I. Minderbroedersstraat 17. 3000 Leusen. Belgium

Abstract

The effect of the beta-blocker atenolol on experimental infarct size was studied in a non-human primate model. In 12 baboons thrombosis of the left anterior descending coronary artery (LAD) was induced and atenolol (0·1 to 0·2 mg . kg–1 intravenously, sufficient to lower the heart rate by 20%) was administered 10 mm after the onset of ischaemia in six animals, whereas the others received placebo. Thrombolysis was induced 60 mm after the onset of ischaemia by intravenous injection of rt PA (12 µg. kg–1. min–1) in all animals.

Heart rate dropped signficantly after atenolol injection (128±9 beats . min–1 versus 163±15 beats . min–1, P<0001) and was also lower than in the control group (128±9 beats. min–1 versus 158±22 beats.min–1, p<0·05). Blood pressure remained unchanged after atenolol treatment. As compared to the control group, atenolol limited infarct size, expressed as a percentage of left ventricular mass (4·6±1·9% versus 7·9±1·3%, P<0·05 or as a percentage of the perfusion area (26±8% versus 43%8%, P<0·05).

Key Words: Experimental myocardial infarction • baboons • infarct size reduction • beta-adrenergic receptor blocking agents


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.